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control casein-based diet td.150303  (Envigo)


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    Envigo control casein-based diet td.150303
    Control Casein Based Diet Td.150303, supplied by Envigo, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/control+casein-based+diet+td%2E150303/control+casein+based+diet+td+150303/pmc09910177-42-9-18
    Average 90 stars, based on 1 article reviews
    control casein-based diet td.150303 - by Bioz Stars, 2026-09
    90/100 stars

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    control casein-based diet td.150303  (Envigo)
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    (A) Flox-Fgf23/Dmp1-Cre mice were placed on <t>casein</t> <t>control</t> or 0.2% adenine <t>diet</t> for 8 weeks. By 4 weeks on diet, serum intact FGF23 levels were significantly elevated in the mice fed adenine diet, yet the levels in flox-Fgf23/Dmp1-Cre+ mice were significantly lower than those in the flox-Fgf23/Dmp1-Cre– mice, which continued at the 8-week time point. (B) Bone Fgf23 mRNA levels rose in the flox-Fgf23/Dmp1-Cre– mice fed adenine at 4 weeks on diet versus casein control. At 8 weeks on diet, the flox-Fgf23/Dmp1-Cre+ adenine-fed mice had significantly lower Fgf23 mRNA compared with flox-Fgf23/Dmp1-Cre–. (C) Serum phosphate levels were found to be similar between flox-Fgf23/Dmp1-Cre– and flox-Fgf23/Dmp1-Cre+ mice at 4 weeks on casein, with an increase in the flox-Fgf23/Dmp1-Cre+ mice at 8 weeks. On adenine diet, the Cre+ mice had a significant increase versus flox-Fgf23/Dmp1-Cre– littermates on the adenine diet at both time points. (D) Blood urea nitrogen (BUN) levels were measured to monitor renal function. As expected, adenine diet increased these levels, but were further elevated in the Cre+ mice on adenine at the 8-week time point. (E) Serum analysis also showed that the adenine diet model induced hyperparathyroidism. All mice receiving adenine had a significant increase in serum PTH compared with the casein control group, even at the 4-week time point. There was no difference between genotypes and there was no further increase at the 8-week time point in the adenine-fed mice (n = 4–6 per group). *P < 0.05, **P < 0.01 versus casein diet within the same genotype; ‡P < 0.05 versus Cre– on the same diet.
    Control Casein Base Rodent Diet (0.9% Phosphate And 0.6% Calcium, Td.150303, supplied by Envigo, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 90 stars, based on 1 article reviews
    control casein-base rodent diet (0.9% phosphate and 0.6% calcium, td.150303 - by Bioz Stars, 2026-09
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    (A) Flox-Fgf23/Dmp1-Cre mice were placed on casein control or 0.2% adenine diet for 8 weeks. By 4 weeks on diet, serum intact FGF23 levels were significantly elevated in the mice fed adenine diet, yet the levels in flox-Fgf23/Dmp1-Cre+ mice were significantly lower than those in the flox-Fgf23/Dmp1-Cre– mice, which continued at the 8-week time point. (B) Bone Fgf23 mRNA levels rose in the flox-Fgf23/Dmp1-Cre– mice fed adenine at 4 weeks on diet versus casein control. At 8 weeks on diet, the flox-Fgf23/Dmp1-Cre+ adenine-fed mice had significantly lower Fgf23 mRNA compared with flox-Fgf23/Dmp1-Cre–. (C) Serum phosphate levels were found to be similar between flox-Fgf23/Dmp1-Cre– and flox-Fgf23/Dmp1-Cre+ mice at 4 weeks on casein, with an increase in the flox-Fgf23/Dmp1-Cre+ mice at 8 weeks. On adenine diet, the Cre+ mice had a significant increase versus flox-Fgf23/Dmp1-Cre– littermates on the adenine diet at both time points. (D) Blood urea nitrogen (BUN) levels were measured to monitor renal function. As expected, adenine diet increased these levels, but were further elevated in the Cre+ mice on adenine at the 8-week time point. (E) Serum analysis also showed that the adenine diet model induced hyperparathyroidism. All mice receiving adenine had a significant increase in serum PTH compared with the casein control group, even at the 4-week time point. There was no difference between genotypes and there was no further increase at the 8-week time point in the adenine-fed mice (n = 4–6 per group). *P < 0.05, **P < 0.01 versus casein diet within the same genotype; ‡P < 0.05 versus Cre– on the same diet.

    Journal: JCI Insight

    Article Title: Increased FGF23 protects against detrimental cardio-renal consequences during elevated blood phosphate in CKD

    doi: 10.1172/jci.insight.123817

    Figure Lengend Snippet: (A) Flox-Fgf23/Dmp1-Cre mice were placed on casein control or 0.2% adenine diet for 8 weeks. By 4 weeks on diet, serum intact FGF23 levels were significantly elevated in the mice fed adenine diet, yet the levels in flox-Fgf23/Dmp1-Cre+ mice were significantly lower than those in the flox-Fgf23/Dmp1-Cre– mice, which continued at the 8-week time point. (B) Bone Fgf23 mRNA levels rose in the flox-Fgf23/Dmp1-Cre– mice fed adenine at 4 weeks on diet versus casein control. At 8 weeks on diet, the flox-Fgf23/Dmp1-Cre+ adenine-fed mice had significantly lower Fgf23 mRNA compared with flox-Fgf23/Dmp1-Cre–. (C) Serum phosphate levels were found to be similar between flox-Fgf23/Dmp1-Cre– and flox-Fgf23/Dmp1-Cre+ mice at 4 weeks on casein, with an increase in the flox-Fgf23/Dmp1-Cre+ mice at 8 weeks. On adenine diet, the Cre+ mice had a significant increase versus flox-Fgf23/Dmp1-Cre– littermates on the adenine diet at both time points. (D) Blood urea nitrogen (BUN) levels were measured to monitor renal function. As expected, adenine diet increased these levels, but were further elevated in the Cre+ mice on adenine at the 8-week time point. (E) Serum analysis also showed that the adenine diet model induced hyperparathyroidism. All mice receiving adenine had a significant increase in serum PTH compared with the casein control group, even at the 4-week time point. There was no difference between genotypes and there was no further increase at the 8-week time point in the adenine-fed mice (n = 4–6 per group). *P < 0.05, **P < 0.01 versus casein diet within the same genotype; ‡P < 0.05 versus Cre– on the same diet.

    Article Snippet: Beginning at 8 weeks of age, mice were provided a control casein-base rodent diet (0.9% phosphate and 0.6% calcium, TD.150303 Envigo).

    Techniques: